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Biofilm matrix exoproteins induce a protective immune response against Staphylococcus aureus biofilm infection
(American Society for Microbiology, 2014)
Artículo / Artikulua,
The Staphylococcus aureus biofilm mode of growth is associated with several chronic infections that are very difficult to treat due
to the recalcitrant nature of biofilms to clearance by antimicrobials. Accordingly, there ...
Evaluation of surface microtopography engineered by direct laser interference for bacterial anti-biofouling
(2015)
Artículo / Artikulua,
Biofilm formation by bacterial pathogens on the surface of medical and industrial settings is a 25 serious health problem. Modification of the biomaterial surface topography is a promising 26 strategy to prevent bacterial ...
Inhibiting the two‑component system GraXRS with verteporfin to combat Staphylococcus aureus infections
(Nature Research, 2020)
Artículo / Artikulua,
Infections caused by Staphylococcus aureus pose a serious and sometimes fatal health issue. With the
aim of exploring a novel therapeutic approach, we chose GraXRS, a Two-Component System (TCS)
that determines bacterial ...
Sensory deprivation in Staphylococcus aureus
(Springer Nature, 2018)
info:eu-repo/semantics/article,
Bacteria use two-component systems (TCSs) to sense and respond to environmental
changes. The core genome of the major human pathogen Staphylococcus aureus encodes 16
TCSs, one of which (WalRK) is essential. Here we show ...
Killing niche competitors by remote-control bacteriophage induction
(National Academy of Sciences, 2009)
info:eu-repo/semantics/article,
A surprising example of interspecies competition is the production
by certain bacteria of hydrogen peroxide at concentrations that are
lethal for others. A case in point is the displacement of Staphylococcus
aureus by ...
SarA positively controls Bap-dependent biofilm formation in Staphylococcus aureus
(American Society for Microbiology, 2005)
info:eu-repo/semantics/article,
The biofilm-associated protein Bap is a staphylococcal surface protein involved in biofilm formation. We
investigated the influence of the global regulatory locus sarA on bap expression and Bap-dependent biofilm
formation ...
Beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus
(American Society for Microbiology, 2006)
info:eu-repo/semantics/article,
Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus
aureus, the antibiotic-induced SOS response promotes replication and high-frequency horizontal transfer ...
Staphylococcus aureus develops an alternative, ica-independent biofilm in the absence of the arlRS two-component system
(American Society for Microbiology, 2005)
info:eu-repo/semantics/article,
The biofilm formation capacity of Staphylococcus aureus clinical isolates is considered an important virulence
factor for the establishment of chronic infections. Environmental conditions affect the biofilm formation
capacity ...
Bap, a biofilm matrix protein of Staphylococcus aureus prevents cellular internalization through binding to GP96 host receptor
(Public Library of Science, 2012)
Artículo / Artikulua,
The biofilm matrix, composed of exopolysaccharides, proteins, nucleic acids and lipids, plays a well-known role as a defence
structure, protecting bacteria from the host immune system and antimicrobial therapy. However, ...
Staphylococcal Bap proteins build amyloid scaffold biofilm matrices in response to environmental signals
(Public Library of Science, 2016)
Artículo / Artikulua,
Major components of the biofilm matrix scaffold are proteins that assemble to create a unified structure that maintain bacteria attached to each other and to surfaces. We provide evidence that a surface protein present in ...