Listar Artículos de revista DCS - OZS Aldizkari artikuluak por título
Mostrando ítems 724-743 de 831
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Signature-driven repurposing of Midostaurin for combination with MEK1/2 and KRASG12C inhibitors in lung cancer
Macaya, Irati; Roman, Marta; Welch, Connor; Entrialgo-Cadierno, Rodrigo; Salmon, Marina; Santos, Alba; Feliu, Iker; Kovalski, Joanna; López Erdozain, Inés; Rodríguez-Remírez, María; Palomino Echeverría, Sara
; Lonfgren, Shane M.; Ferrero, Macarena; Calabuig, Silvia; Ludwig, Iziar A.; Lara-Astiaso, David; Jantus-Lewintre, Eloisa; Guruceaga, Elizabeth; Narayanan, Shruthi; Ponz Sarvisé, Mariano; Pineda Lucena, Antonio; Lecanda, Fernando; Ruggero, Davide; Khatri, Purvesh; Santamaría, Enrique; Fernández Irigoyen, Joaquín ; Ferrer, Irene; Paz-Ares, Luis; Drosten, Matthias; Barbacid, Mariano; Gil-Bazo, Ignacio; Vicent, Silvestre (Springer Nature, 2023)
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Drug combinations are key to circumvent resistance mechanisms compromising response to single anti-cancer targeted therapies. The implementation of combinatorial approaches involving MEK1/2 or KRASG12C inhibitors in the ... -
El silencio social que se construye en torno al aborto inducido
Ortega Larrea, Susana; García-Orellán, Rosa ; Ortega Larrea, Ana (Fundación Index, 2016)
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Objetivo: analizar la experiencia de las mujeres que han tenido un aborto y las consecuencias dolorosas que dicha práctica produce en la vida y en el cuerpo de las mujeres, así como averiguar si existe un apoyo social para ... -
Similar cardiometabolic effects of high- and moderate-intensity training among apparently healthy inactive adults: a randomized clinical trial
Ramírez Vélez, Robinson ; Tordecilla Sanders, Alejandra; Téllez Tinjaca, Luis Andrés; Camelo Prieto, Diana; Hernández Quiñonez, Paula Andrea; Correa Bautista, Jorge Enrique; García Hermoso, Antonio; Ramírez Campillo, Rodrigo; Izquierdo Redín, Mikel (BioMed Central, 2017)
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Background: Metabolic syndrome (MetS) increases the risk of morbidity and mortality from cardiovascular disease, and exercise training is an important factor in the treatment and prevention of the clinical components of ... -
Simulación clínica y la pandemia por COVID-19. ¿De dónde venimos? ¿Hacia dónde queremos ir?
Batllori Gastón, Mikel (Gobierno de Navarra. Departamento de Salud, 2020)
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Se trata el tema de la simulación clínica y se pone de manifiesto sus ventajas en actividad clínica consecuencia de la pandemia de Covid-19, esbozando la situación actual y las perspectivas de futuro. -
Single nucleotide polymorphisms of ADIPOQ gene associated with cardiovascular disease risk factors in European adolescents: the HELENA study
Salazar-Tortosa, Diego; Pascual Gamarra, José Miguel; Labayen Goñi, Idoia ; Rupérez, Azahara I.; Censi, Laura; Béghin, Laurent; Michels, Nathalie; González Gross, Marcela; Manios, Yannis; Lambrinou, Christina-Paulina; Moreno, Luis A.; Meirhaeghe, Aline; Castillo, Manuel J.; Ruiz, Jonatan R. (Wolters Kluwer, 2020)
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Objectives: Cardiovascular diseases (CVDs) are responsible of 31% of all deaths worldwide. Genetic predisposition to CVDs in adolescents remains largely unknown. Aims of present research are to examine the association of ... -
Sit to stand muscle power reference values and their association with adverse events in Colombian older adults
(Nature Research, 2022) Artículo / Artikulua
Recently, a valid method to assess lower-body muscle power based on a sit-to-stand feld test (STS) has been published. Our study aimed to describe lower-body muscle power in older individuals aged≥ 60 years and examine ... -
Six-month breastfeeding maintenance after a self-efficacy promoting programme: an exploratory trial
Antoñanzas Baztán, Elena ; Belintxon, Maider; Marín Fernández, Blanca ; Redín Areta, María Dolores ; Mujika Zabaleta, Agurtzane; Pumar Méndez, María Jesús ; López de Dicastillo Sáinz de Murieta, Olga (Wiley, 2021)
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Background: Breastfeeding care plays a fundamental role in establishing breastfeeding and longer duration after discharge. Practices though vary among professionals involved and are often inconsistent with good practices ... -
Smartwatch ECG tracing and ischemic heart disease: ACS watch study
(Karger, 2023) Artículo / Artikulua
BACKGROUND: Smartwatches have become a widely used tool for health self-care. Its role in ischemic heart disease (IHD) has not been assessed. OBJECTIVES: To evaluate the usefulness of smartwatch ECG registry in IHD. METHODS: ... -
Smelling the dark proteome: functional characterization of PITH domain-containing protein 1 (C1orf128) in olfactory metabolism
Lachén Montes, Mercedes ; Mendizuri, Naroa; Ausín, Karina; Pérez Mediavilla, Alberto; Azkargorta, Mikel; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Iloro, Ibon; Elortza, Félix; Kondo, Hiroyuki; Ohigashi, Izumi; Ferrer, Isidro; Torre, Rafael de la; Robledo, Patricia (ACS Publications, 2020)
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The Human Proteome Project (HPP) consortium aims to functionally characterize the dark proteome. On the basis of the relevance of olfaction in early neurodegeneration, we have analyzed the dark proteome using data mining ... -
Soccer attenuates the asymmetry of rectus abdominis muscle observed in non-athletes
Idoate, Fernando; López Calbet, José Antonio; Izquierdo Redín, Mikel ; Sanchís Moysi, Joaquín (Public Library of Science, 2011)
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Purpose: To determine the volume and degree of asymmetry of the rectus abdominis muscle (RA) in professional soccer players. Methods: The volume of the RA was determined using magnetic resonance imaging (MRI) in 15 ... -
A sociodemographic, anthropometric and lifestyle-based prediction score for screening children with overweight and obesity for hepatic steatosis: the HEPAKID index
Osés Recalde, Maddi ; Medrano Echeverría, María ; Galbete Jiménez, Arkaitz ; Arenaza, Lide ; Ruiz, Jonatan R.; Sánchez-Valverde, Felix; Ortega, Francisco B.; Labayen Goñi, Idoia (Wiley, 2021)
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Background: Hepatic steatosis (HS) is currently the most prevalent hepatic disease in paediatric population and a major risk factor for type 2 diabetes and cardiovascular diseases. The proper identification of children ... -
Socioeconomic inequalities in cardiometabolic control in patients with type 2 diabetes
Ibáñez Beroiz, B. ; Galbete Jiménez, Arkaitz ; Goñi, María José; Forga, Lluís; Cambra Contin, Koldo (BioMed Central, 2018)
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Background: The aim of this study was to determine if the achievement of control targets in patients with type 2 diabetes was associated with personal socioeconomic factors and if these associations were sex-dependent. ... -
Soluble ST2 as a new oxidative stress and inflammation marker in metabolic syndrome
(MDPI, 2023) Artículo / Artikulua
Background: Metabolic syndrome (MS) is a complex and prevalent disorder. Oxidative stress and inflammation might contribute to the progression of MS. Soluble ST2 (sST2) is an attractive and druggable molecule that sits at ... -
Solution-focused versus problem-focused questions: differential effects of miracles, exceptions and scales
Neipp López, María del Carmen; Beyebach, Mark ; Sánchez Prada, Andrés; Delgado Álvarez, María del Carmen (Wiley, 2021)
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The differential impact of solution-focused brief therapy questions was tested. A total of 246 subjects described a personal problem they wanted to solve and were randomly assigned to one of four interventions that involved ... -
Spanish HTT gene study reveals haplotype and allelic diversity with possible implications for germline expansion dynamics in Huntington disease
Ruiz de Sabando, Ainara; Urrutia Lafuente, Edurne; Galbete Jiménez, Arkaitz ; Ciosi, Marc; García Amigot, Fermín; García Solaesa, Virginia; Monckton, Darren G.; Ramos Arroyo, María A. (Oxford University Press, 2023)
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We aimed to determine the genetic diversity and molecular characteristics of the Huntington disease (HD) gene (HTT) in Spain. We performed an extended haplotype and exon one deep sequencing analysis of the HTT gene in a ... -
The Spanish version of the child medical fear questionnaire: cross-cultural adaptation and validation
San Martín Rodríguez, Leticia ; Soto Ruiz, María Nelia ; Ferraz Torres, Marta ; García Vivar, Cristina ; Saralegui Gainza, Amaia; Escalada Hernández, Paula (MDPI, 2021)
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Having valid and reliable tools that help health professionals to assess fear in children undergoing medical procedures is essential to offer humanised and quality of care in the paediatric population. The aim of this study ... -
Spatial and temporal proteome dynamics of glioma cells during oncolytic adenovirus Delta-24-RGD infection
González Morales, Andrea ; Zabaleta, Aintzane; Guruceaga, Elizabeth; Alonso Roldán, Marta ; García Moure, Marc (Impact Journals, 2018)
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Glioblastoma multiforme (GBM) is the most common and aggressive type of malignant glioma. Oncolytic adenoviruses are being modified to exploit the aberrant expression of proteins in tumor cells to increase the antiglioma ... -
Specific multimorbidity patterns modify the impact of an exercise intervention in older hospitalized adults
Martínez Velilla, Nicolás; Galbete Jiménez, Arkaitz ; Roso Llorach, Albert; Zambom Ferraresi, Fabrício ; López Sáez de Asteasu, Mikel; Izquierdo Redín, Mikel; Vetrano, Davide L.; Calderón Larrañaga, Amaia (SAGE, 2022)
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Background: Different multimorbidity patterns present with different prognoses, but it is unknown to what extent they may influence the effectiveness of an individualized multicomponent exercise program offered to hospitalized ... -
Splicing events in the control of genome integrity: role of SLU7 and truncated SRSF3 proteins
Jiménez, Maddalen; Urtasun Alonso, Raquel ; Elizalde, María; Azkona, María; Latasa, Maria Ujue; Uriarte, Iker; Arechederra, María; Alignani, Diego; Bárcena-Varela, Marina; Álvarez-Sola, Gloria; Colyn, Leticia; Santamaría, Eva; Sangro, Bruno; Rodriguez-Ortigosa, Carlos; Fernández-Barrena, Maite G.; Ávila, Matías A.; Berasain, Carmen (Oxford University Press, 2019)
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Genome instability is related to disease development and carcinogenesis. DNA lesions are caused by genotoxic compounds but also by the dysregulation of fundamental processes like transcription, DNA replication and mitosis. ... -
Splicing factor SLU7 prevents oxidative stress-mediated hepatocyte nuclear factor 4α degradation, preserving hepatic differentiation and protecting from liver damage
Gárate Rascón, María; Recalde, Miriam; Jiménez, Maddalen; Elizalde, María; Azkona, María; Uriarte, Iker; Latasa, Maria Ujue; Urtasun Alonso, Raquel ; Bilbao, Idoia; Sangro, Bruno; García Ruiz, Carmen; Fernández-Checa, José Carlos; Corrales, Fernando J.; Esquivel, Argitxu; Pineda Lucena, Antonio; Fernández-Barrena, Maite G.; Ávila, Matías A.; Arechederra, María; Berasain, Carmen (WileyAmerican Asociation for the Study of Liver Diseases, 2021)
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Background and Aims: Hepatocellular dedifferentiation is emerging as an important determinant in liver disease progression. Preservation of mature hepatocyte identity relies on a set of key genes, predominantly the ...
