Effects of exercise on bone marrow adipose tissue in children with overweight/obesity: role of liver fat

Date

2024-08-07

Authors

Idoate, Fernando
Gracia-Marco, Luis
Alfaro-Magallanes, Víctor Manuel
Rodríguez Vigil, Beatriz
Ortega, Francisco B.

Director

Publisher

Oxford University Press
Acceso abierto / Sarbide irekia
Artículo / Artikulua
Versión publicada / Argitaratu den bertsioa

Project identifier

  • MINECO//PI13%2F01335/ES/ recolecta
  • //DEP2016-78377-R/
  • Gobierno de Navarra//0011-1365-2019-000152/
  • Gobierno de Navarra//0011-1365-2020-000243/
Impacto
OpenAlexGoogle Scholar
cited by count

Abstract

Context: Exercise reduces adiposity, but its influence on bone marrow fat fraction (BMFF) is unknown; nor is it known whether a reduction in liver fat content mediates this reduction. Objectives: This work aimed to determine whether incorporating exercise into a lifestyle program reduces the lumbar spine (LS) BMFF and to investigate whether changes in liver fat mediate any such effect.Methods Ancillary analysis of a 2-arm, parallel, nonrandomized clinical trial was conducted at primary care centers in Vitoria-Gasteiz, Spain. A total of 116 children with overweight/obesity were assigned to a 22-week family-based lifestyle program (control group [n = 57]) or the same program plus an exercise intervention (exercise group [n = 59]). The compared interventions consisted of a family-based lifestyle program (two 90-minute sessions/month) and the same program plus supervised exercise (three 90-minute sessions/week). The primary outcome examined was the change in LS-BMFF between baseline and 22 weeks, as estimated by magnetic resonance imaging. The effect of changes in hepatic fat on LS-BMFF were also recorded.Results Mean weight loss difference between groups was 1.4 +/- 0.5 kg in favor of the exercise group. Only the children in the exercise group experienced a reduction in LS-BMFF (effect size [Cohen d] -0.42; CI, -0.86 to -0.01). Importantly, 40.9% of the reductions in LS-BMFF were mediated by changes in percentage hepatic fat (indirect effect: beta=-0.104; 95% CI, -0.213 to -0.019). The effect of changes in hepatic fat on LS-BMFF was independent of weight loss.Conclusion The addition of exercise to a family-based lifestyle program designed to reduce cardiometabolic risk improves bone health by reducing LS-BMFF in children with overweight or obesity. This beneficial effect on bone marrow appears to be mediated by reductions in liver fat.

Description

Keywords

Bone health, Obesity, Fatty liver, MAFLD, MASLD, NAFLD, Youth, Lifestyle

Department

Ingeniería Eléctrica, Electrónica y de Comunicación / Ingeniaritza Elektrikoa, Elektronikoa eta Telekomunikazio Ingeniaritza / Agronomía, Biotecnología y Alimentación / Agronomia, Bioteknologia eta Elikadura / Ciencias de la Salud / Osasun Zientziak / Institute of Smart Cities - ISC / Institute on Innovation and Sustainable Development in Food Chain - ISFOOD

Faculty/School

Degree

Doctorate program

item.page.cita

Labayen, I., Cadenas-Sánchez, C., Idoate, F., Gracia-Marco, L., Medrano, M., Alfaro-Magallanes, V. M., Alcantara, J. M. A., Rodríguez-Vigil, B., Osés, M., Ortega, F. B., Ruiz, J. R., Cabeza, R. (2024). Effects of exercise on bone marrow adipose tissue in children with overweight/obesity: role of liver fat. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/clinem/dgae547.

item.page.rights

© The Author(s) 2024. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited

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