Effects of exercise on bone marrow adipose tissue in children with overweight/obesity: role of liver fat

Simple item page
dc.contributor.authorLabayen Goñi, Idoia
dc.contributor.authorCadenas-Sánchez, Cristina
dc.contributor.authorIdoate, Fernando
dc.contributor.authorGracia-Marco, Luis
dc.contributor.authorMedrano Echeverría, María
dc.contributor.authorAlfaro-Magallanes, Víctor Manuel
dc.contributor.authorAlcántara Alcántara, Juan Manuel
dc.contributor.authorRodríguez Vigil, Beatriz
dc.contributor.authorOsés Recalde, Maddi
dc.contributor.authorOrtega, Francisco B.
dc.contributor.authorRuiz, Jonatan R.
dc.contributor.authorCabeza Laguna, Rafael
dc.contributor.departmentIngeniería Eléctrica, Electrónica y de Comunicaciónes_ES
dc.contributor.departmentIngeniaritza Elektrikoa, Elektronikoa eta Telekomunikazio Ingeniaritzaeu
dc.contributor.departmentAgronomía, Biotecnología y Alimentaciónes_ES
dc.contributor.departmentAgronomia, Bioteknologia eta Elikaduraeu
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.departmentInstitute of Smart Cities - ISCen
dc.contributor.departmentInstitute on Innovation and Sustainable Development in Food Chain - ISFOODen
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua
dc.date.accessioned2024-11-13T12:55:55Z
dc.date.available2024-11-13T12:55:55Z
dc.date.issued2024-08-07
dc.date.updated2024-11-13T12:38:03Z
dc.description.abstractContext: Exercise reduces adiposity, but its influence on bone marrow fat fraction (BMFF) is unknown; nor is it known whether a reduction in liver fat content mediates this reduction. Objectives: This work aimed to determine whether incorporating exercise into a lifestyle program reduces the lumbar spine (LS) BMFF and to investigate whether changes in liver fat mediate any such effect.Methods Ancillary analysis of a 2-arm, parallel, nonrandomized clinical trial was conducted at primary care centers in Vitoria-Gasteiz, Spain. A total of 116 children with overweight/obesity were assigned to a 22-week family-based lifestyle program (control group [n = 57]) or the same program plus an exercise intervention (exercise group [n = 59]). The compared interventions consisted of a family-based lifestyle program (two 90-minute sessions/month) and the same program plus supervised exercise (three 90-minute sessions/week). The primary outcome examined was the change in LS-BMFF between baseline and 22 weeks, as estimated by magnetic resonance imaging. The effect of changes in hepatic fat on LS-BMFF were also recorded.Results Mean weight loss difference between groups was 1.4 +/- 0.5 kg in favor of the exercise group. Only the children in the exercise group experienced a reduction in LS-BMFF (effect size [Cohen d] -0.42; CI, -0.86 to -0.01). Importantly, 40.9% of the reductions in LS-BMFF were mediated by changes in percentage hepatic fat (indirect effect: beta=-0.104; 95% CI, -0.213 to -0.019). The effect of changes in hepatic fat on LS-BMFF was independent of weight loss.Conclusion The addition of exercise to a family-based lifestyle program designed to reduce cardiometabolic risk improves bone health by reducing LS-BMFF in children with overweight or obesity. This beneficial effect on bone marrow appears to be mediated by reductions in liver fat.en
dc.description.sponsorshipThis work was supported by the Fondos de Investigacion Sanitaria del Instituto de Salud Carlos III (PI13/01335), the Spanish Ministry of Economy and Competitiveness (DEP2016-78377-R), and by the European Regional Development Fund (ERDF): Una Manera de Hacer Europa. Support was also provided by the Department of Economic Development of the Government of Navarra (0011-1365-2019-000152 and 0011-1365-2020-000243), cofunded by European Regional Development Fund (ERDF 2014-2020 for Navarra). C.C.S. is supported by the Spanish Ministry of Science and Innovation (FJC2018-037925-I). J.M.A.A. is supported by the MCIN/AEI/ 10.13039/501100011033 and by European Union Next Generation Funds EU/PRTR funds (FJC2020-044453-I). M.O. is supported by the Spanish Ministry of Economy and Competitiveness (BES-2017-080770). V.M.A.M. is supported by a Margarita Salas grant RCMS-22-KIAO1C-24-GSMTDX, which is funded by the MCIN/AEI/10.13039/501100011033 and the European Union.
dc.format.mimetypeapplication/pdfen
dc.identifier.citationLabayen, I., Cadenas-Sánchez, C., Idoate, F., Gracia-Marco, L., Medrano, M., Alfaro-Magallanes, V. M., Alcantara, J. M. A., Rodríguez-Vigil, B., Osés, M., Ortega, F. B., Ruiz, J. R., Cabeza, R. (2024). Effects of exercise on bone marrow adipose tissue in children with overweight/obesity: role of liver fat. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/clinem/dgae547.
dc.identifier.doi10.1210/clinem/dgae547
dc.identifier.issn0021-972X
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/52501
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofThe Journal of Clinical Endocrinology & Metabolism (2024)
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI13%2F01335/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement///DEP2016-78377-R/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//0011-1365-2019-000152/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//0011-1365-2020-000243/
dc.relation.publisherversionhttps://doi.org/10.1210/clinem/dgae547
dc.rights© The Author(s) 2024. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBone healthen
dc.subjectObesityen
dc.subjectFatty liveren
dc.subjectMAFLDen
dc.subjectMASLDen
dc.subjectNAFLDen
dc.subjectYouthen
dc.subjectLifestyleen
dc.titleEffects of exercise on bone marrow adipose tissue in children with overweight/obesity: role of liver faten
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationb36e2b1d-3088-4089-806e-fd3040e9583a
relation.isAuthorOfPublicationeeecebce-3369-4e9a-8372-894379eeaa96
relation.isAuthorOfPublication304856ca-cc85-4094-8ca3-b17f4c5f33de
relation.isAuthorOfPublication81010fc5-9a1b-44dd-8cfe-933acda93159
relation.isAuthorOfPublicationa3f4aa23-172a-47fb-9faf-647f655f7085
relation.isAuthorOfPublication42fe20f8-5341-4c0e-8686-333ce816adfd
relation.isAuthorOfPublication.latestForDiscoveryb36e2b1d-3088-4089-806e-fd3040e9583a

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Labayen_EffectsExercise.pdf
Size:
661.44 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description:
Download

Collections

Artículos de revista DIEC - IEKS Aldizkari artikuluak
Artículos de revista - Aldizkari artikuluak
Artículos de revista DABA - ABES Aldizkari artikuluak
Artículos de revista DCS - OZS Aldizkari artikuluak
Artículos de revista ISC - ISC aldizkari artikuluak
Artículos de revista ISFOOD - ISFOOD aldizkari artikuluak