• Amyloid structures as biofilm matrix scaffolds 

      Taglialegna, Agustina Upna; Lasa Uzcudun, Íñigo Upna Orcid; Valle Turrillas, Jaione Upna Orcid (American Society for Microbiology, 2016)   Artículo / Artikulua  OpenAccess
      Recent insights into bacterial biofilm matrix structures have induced a paradigm shift toward the recognition of amyloid fibers as common building block structures that confer stability to the exopolysaccharide matrix. ...
    • Analysis of the role of the LH92_11085 gene of a biofilm hyper-producing Acinetobacter baumannii strain on biofilm formation and attachment to eukaryotic cells 

      Álvarez Fraga, Laura; Pérez, Astrid; Rumbo Feal, Soraya; Merino, María; Valle Turrillas, Jaione Upna Orcid (Taylor & Francis, 2016)   Artículo / Artikulua  OpenAccess
      Acinetobacter baumannii is a nosocomial pathogen that has a considerable ability to survive in the hospital environment partly due to its capacity to form biofilms. The first step in the process of establishing an infection ...
    • B regulates IS256-mediated Staphylococcus aureus biofilm phenotypic variation 

      Valle Turrillas, Jaione Upna Orcid; Vergara Irigaray, Marta Upna; Merino, Nekane Upna; Penadés, José R.; Lasa Uzcudun, Íñigo Upna Orcid (American Society for Microbiology, 2007)   Artículo / Artikulua  OpenAccess
      Biofilm formation in Staphylococcus aureus is subject to phase variation, and biofilm-negative derivatives emerge sporadically from a biofilm-positive bacterial population. To date, the only known mechanism for generating ...
    • Bap, a biofilm matrix protein of Staphylococcus aureus prevents cellular internalization through binding to GP96 host receptor 

      Valle Turrillas, Jaione Upna Orcid; Latasa Osta, Cristina Upna; Gil Puig, Carmen Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Solano Goñi, Cristina Upna Orcid; Penadés, José R.; Lasa Uzcudun, Íñigo Upna Orcid (Public Library of Science, 2012)   Artículo / Artikulua  OpenAccess
      The biofilm matrix, composed of exopolysaccharides, proteins, nucleic acids and lipids, plays a well-known role as a defence structure, protecting bacteria from the host immune system and antimicrobial therapy. However, ...
    • Bap, a Staphylococcus aureus surface protein involved in biofilm formation 

      Cucarella, Carme; Solano Goñi, Cristina Upna Orcid; Valle Turrillas, Jaione Upna Orcid; Amorena Zabalza, Beatriz Upna; Lasa Uzcudun, Íñigo Upna Orcid; Penadés, José R. (American Society for Microbiology, 2001)   Artículo / Artikulua  OpenAccess
      Identification of new genes involved in biofilm formation is needed to understand the molecular basis of strain variation and the pathogenic mechanisms implicated in chronic staphylococcal infections. A biofilm-producing ...
    • Base pairing interaction between 5′- and 3′-UTRs controls icaR mRNA translation in Staphylococcus aureus 

      Ruiz de los Mozos Aliaga, Igor Upna; Vergara Irigaray, Marta Upna; Segura, Víctor; Villanueva San Martín, Maite Upna Orcid; Bitarte, Nerea Upna; Saramago, Margarida; Domingues, Susana; Arraiano, Cecilia M.; Fechter, Pierre; Romby, Pascale; Valle Turrillas, Jaione Upna Orcid; Solano Goñi, Cristina Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid; Toledo Arana, Alejandro Upna Orcid (Public Library of Science, 2013)   Artículo / Artikulua  OpenAccess
      The presence of regulatory sequences in the 39 untranslated region (39-UTR) of eukaryotic mRNAs controlling RNA stability and translation efficiency is widely recognized. In contrast, the relevance of 39-UTRs in bacterial ...
    • Biofilm matrix exoproteins induce a protective immune response against Staphylococcus aureus biofilm infection 

      Gil Puig, Carmen Upna Orcid; Solano Goñi, Cristina Upna Orcid; Burgui Erice, Saioa Upna Orcid; Latasa Osta, Cristina Upna; García Martínez, Begoña Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid; Valle Turrillas, Jaione Upna Orcid (American Society for Microbiology, 2014)   Artículo / Artikulua  OpenAccess
      The Staphylococcus aureus biofilm mode of growth is associated with several chronic infections that are very difficult to treat due to the recalcitrant nature of biofilms to clearance by antimicrobials. Accordingly, there ...
    • Biofilm switch and immune response determinants at early stages of infection 

      Valle Turrillas, Jaione Upna Orcid; Solano Goñi, Cristina Upna Orcid; García Martínez, Begoña Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid (Elsevier (Cell Press), 2013)   Artículo / Artikulua  OpenAccess
      Biofilm development is recognized as a major virulence factor underlying most chronic bacterial infections. When a biofilm community is established, planktonic cells growing in the surroundings of a tissue switch to a ...
    • Coordinated cyclic-di-GMP repression of salmonella motility through YcgR and cellulose 

      Zorraquino Salvo, Violeta; García Martínez, Begoña Upna Orcid; Latasa Osta, Cristina Upna; Echeverz Sarasúa, Maite Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Valle Turrillas, Jaione Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid; Solano Goñi, Cristina Upna Orcid (American Society for Microbiology, 2013)   Artículo / Artikulua  OpenAccess
      Cyclic di-GMP (c-di-GMP) is a secondary messenger that controls a variety of cellular processes, including the switch between a biofilm and a planktonic bacterial lifestyle. This nucleotide binds to cellular effectors in ...
    • The enterococcal surface protein, Esp, is involved in Enterococcus faecalis biofilm formation 

      Toledo Arana, Alejandro Upna Orcid; Valle Turrillas, Jaione Upna Orcid; Solano Goñi, Cristina Upna Orcid; Arrizubieta Balerdi, María Jesús Upna; Cucarella, Carme; Lamata, Marta; Amorena Zabalza, Beatriz Upna; Leiva, José; Penadés, José R.; Lasa Uzcudun, Íñigo Upna Orcid (American Society for Microbiology, 2001)   Artículo / Artikulua  OpenAccess
      The enterococcal surface protein, Esp, is a high-molecular-weight surface protein of unknown function whose frequency is significantly increased among infection-derived Enterococcus faecalis isolates. In this work, a ...
    • Evaluation of surface microtopography engineered by direct laser interference for bacterial anti-biofouling 

      Valle Turrillas, Jaione Upna Orcid; Burgui Erice, Saioa Upna Orcid; Langheinrich, Denise; Gil Puig, Carmen Upna Orcid; Solano Goñi, Cristina Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Helbig, Ralf; Lasagni, Andrés; Lasa Uzcudun, Íñigo Upna Orcid (2015)   Artículo / Artikulua  OpenAccess
      Biofilm formation by bacterial pathogens on the surface of medical and industrial settings is a 25 serious health problem. Modification of the biomaterial surface topography is a promising 26 strategy to prevent bacterial ...
    • Genetic reductionist approach for dissecting individual roles of GGDEF proteins within the c-di-GMP signaling network in Salmonella 

      Solano Goñi, Cristina Upna Orcid; García Martínez, Begoña Upna Orcid; Latasa Osta, Cristina Upna; Toledo Arana, Alejandro Upna Orcid; Zorraquino Salvo, Violeta; Valle Turrillas, Jaione Upna Orcid; Casals, Joan; Pedroso, Enrique; Lasa Uzcudun, Íñigo Upna Orcid (National Academy of Sciences, 2009)   Artículo / Artikulua  OpenAccess
      Bacteria have developed an exclusive signal transduction system involving multiple diguanylate cyclase and phosphodiesterase domain-containing proteins (GGDEF and EAL/HD-GYP, respectively) that modulate the levels of the ...
    • Genome-wide antisense transcription drives mRNA processing in bacteria 

      Lasa Uzcudun, Íñigo Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Dobin, Alexander; Villanueva San Martín, Maite Upna Orcid; Ruiz de los Mozos Aliaga, Igor Upna; Vergara Irigaray, Marta Upna; Segura, Víctor; Fagegaltier, Delphine; Penadés, José R.; Valle Turrillas, Jaione Upna Orcid; Solano Goñi, Cristina Upna Orcid; Gingeras, Thomas R. (National Academy of Sciences, 2011)   Artículo / Artikulua  OpenAccess
      RNA deep sequencing technologies are revealing unexpected levels of complexity in bacterial transcriptomes with the discovery of abundant noncoding RNAs, antisense RNAs, long 5′ and 3′ untranslated regions, and alternative ...
    • Global assessment of small RNAs reveals a non-coding transcript involved in biofilm formation and attachment in Acinetobacter baumannii ATCC 17978 

      Álvarez Fraga, Laura; Rumbo Feal, Soraya; Pérez, Astrid; Gómez, Manuel J.; Valle Turrillas, Jaione Upna Orcid (Public Library of Science, 2017)   Artículo / Artikulua  OpenAccess
      Many strains of Acinetobacter baumannii have been described as being able to form biofilm. Small non-coding RNAs (sRNAs) control gene expression in many regulatory circuits in bacteria. The aim of the present work was to ...
    • Lack of the PGA exopolysaccharide in Salmonella as an adaptive trait for survival in the host 

      Echeverz Sarasúa, Maite Upna Orcid; García Martínez, Begoña Upna Orcid; Sabalza Baztán, Amaia Upna; Valle Turrillas, Jaione Upna Orcid; Gabaldón Estevan, Juan Antonio; Solano Goñi, Cristina Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid (Public Library of Science, 2017)   Artículo / Artikulua  OpenAccess
      Many bacteria build biofilm matrices using a conserved exopolysaccharide named PGA or PNAG (poly-β-1,6-N-acetyl-D-glucosamine). Interestingly, while E. coli and other members of the family Enterobacteriaceae encode the ...
    • Near-infrared fluorescence imaging as an alternative to bioluminescent bacteria to monitor biomaterial-associated infections 

      Dinjaski, Nina; Shalu, Suri; Valle Turrillas, Jaione Upna Orcid; Lehman, Susan M.; Lasa Uzcudun, Íñigo Upna Orcid; Prieto, María Auxiliadora; García, Andrés J. (Elsevier, 2014)   Artículo / Artikulua  OpenAccess
      Biomaterial-associated infection is one of the most common complications related with the implantation of any biomedical device. Several in vivo imaging platforms have emerged as powerful diagnostic tools to longitudinally ...
    • Noncontiguous operon is a genetic organization for coordinating bacterial gene expression 

      Sáenz Lahoya, S.; Bitarte, Nerea Upna; García, Beñat; Burgui Erice, Saioa Upna Orcid; Vergara Irigaray, Marta Upna; Valle Turrillas, Jaione Upna Orcid; Solano Goñi, Cristina Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid (National Academy of Sciences, 2019)   Artículo / Artikulua  OpenAccess
      Bacterial genes are typically grouped into operons defined as clusters of adjacent genes encoding for proteins that fill related roles and are transcribed into a single polycistronic mRNA molecule. This simple organization ...
    • Protein A-mediated multicellular behavior in Staphylococcus aureus 

      Merino, Nekane Upna; Toledo Arana, Alejandro Upna Orcid; Vergara Irigaray, Marta Upna; Valle Turrillas, Jaione Upna Orcid; Solano Goñi, Cristina Upna Orcid; Calvo, Enrique; Lopez, Juan Antonio; Foster, Timothy J.; Penadés, José R.; Lasa Uzcudun, Íñigo Upna Orcid (American Society for Microbiology, 2008)   Artículo / Artikulua  OpenAccess
      The capacity of Staphylococcus aureus to form biofilms on host tissues and implanted medical devices is one of the major virulence traits underlying persistent and chronic infections. The matrix in which S. aureus cells ...
    • Regulation of heterogenous lexA expression in staphylococcus aureus by an antisense RNA originating from transcriptional read-through upon natural mispairings in the sbrB intrinsic terminator 

      Bastet, Laurène; Bustos-Sanmamed, Pilar; Catalán Moreno, Arancha; Caballero Sánchez, Carlos Upna; Cuesta Ferre, Sergio; Matilla Cuenca, Leticia Upna Orcid; Villanueva San Martín, Maite Upna Orcid; Valle Turrillas, Jaione Upna Orcid; Lasa Uzcudun, Íñigo; Toledo Arana, Alejandro (MDPI, 2022)   Artículo / Artikulua  OpenAccess
      Bacterial genomes are pervasively transcribed, generating a wide variety of antisense RNAs (asRNAs). Many of them originate from transcriptional read-through events (TREs) during the transcription termination process. ...
    • Relative contribution of P5 and hap surface proteins to nontypable haemophilus influenzae interplay with the host upper and lower airways 

      Euba, Begoña; Moleres Apilluelo, Javier Upna Orcid; Viadas Martínez, Cristina Upna; Ruiz de los Mozos Aliaga, Igor Upna; Valle Turrillas, Jaione Upna Orcid; Bengoechea Alonso, José Antonio; Garmendia García, Juncal (Public Library of Science, 2015)   Artículo / Artikulua  OpenAccess
      Nontypable Haemophilus influenzae (NTHi) is a major cause of opportunistic respiratory tract disease, and initiates infection by colonizing the nasopharynx. Bacterial surface proteins play determining roles in the ...

      El Repositorio ha recibido la ayuda de la Fundación Española para la Ciencia y la Tecnología para la realización de actividades en el ámbito del fomento de la investigación científica de excelencia, en la Línea 2. Repositorios institucionales (convocatoria 2020-2021).
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